Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 7, Pages 1724-1728Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400831p
Keywords
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Funding
- Medical Research Center Program (MRC) through the National Research Foundation of Korea [2008-0062275]
- Inter-ER Cooperation Projects through the Ministry of Knowledge Economy (MKE), Korea Institute for Advancement of Technology (KIAT) [R0002019]
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Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl2-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC50 values ranging from 16.8 to 49.3 mu M. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1 beta production with IC50 values ranging from 8.6 to 38.9 mu M in RAW 264.7 macrophages.
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