Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 5, Pages 1210-1214Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500119e
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Funding
- Queensland Government Smart Futures NIRAP Program
- Australian Research Council [LE0668477, LE0237908]
- Alzheimer's Drug Discovery Foundation
- Centre for Drug Research and Development (Vancouver, Canada)
- Australian Research Council [LE0668477, LE0237908] Funding Source: Australian Research Council
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Mass-directed fractionation of an extract from the Australian marine sponge Aplysinella sp., from the Great Barrier Reef, resulted in the isolation of four new bromotyrosine derivatives, aplysinellamides A-C (1-3) and aplysamine-1-N-oxide (4), along with six known compounds (5-10). The structure elucidation of compounds 1-4 was based on their 1D and 2D NMR and MS spectroscopic data. Aplysamine-1 (6) increased the apolipoprotein E secretion from human CCF-STTG1 astrocytoma cells by 2-fold at the concentration of 30 mu M.
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