Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 2, Pages 270-275Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400833x
Keywords
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Funding
- National Natural Science Fundation of China [41176120, 21372208]
- Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province [BS2010HZ027]
- National High Technology Research and Development Program of China [2013AA092901]
- Program for New Century Excellent Talents in University [NCET-12-0499]
- Public Projects of State Oceanic Administration [2010418022-3]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0944]
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Five new fungal hybrid polyketides, cladosins A-D (1-4), that contain a novel linear 6(3)-enamino-8,10-dihydroxy-tetraketide (1 and 2) or 6-enamino-7(8)-en-10-ol (3 and 4) moiety, as well as the biogenetically related cladosin E (5), were isolated from the deep-sea-derived fungus Cladosporium sphaerospermum 2005-01-E3. Their structures (1-5) were elucidated through a combination of spectroscopic data, chemical conversion, and both Mosher's and Marfey's methods for stereochemical assignment. A plausible biogenetic pathway to 1-5 is proposed. Cladosin C (3) possesses mild anti-influenza A H1N1 virus activity.
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