Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 2, Pages 424-428Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400977e
Keywords
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Funding
- National Natural Science Foundation of China [41176120, 21372208]
- National High Technology Research and Development Program of China [2013AA092901]
- Program for New Century Excellent Talents in University [NCET-12-0499]
- Public Projects of State Oceanic Administration [2010418022-3]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0944]
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Two novel sorbicillinoids combining a bicyclo[2.2.2]octane with a 2-methoxyphenol moiety, named sorbicatechols A (1) and B (2), were isolated from the culture of the Marine sediment-derived fungus Penicillium chrysogenum PJX-17, together with the known protocatechuic acid methyl ester and caffeic acid methyl ester (3). Their structures, including absolute configurations, were assigned by analysis of NMR, MS data, and TDDFT ECD calculations. Compounds 1 and 2 exhibited activities against influenza virus A (H1N1), with IC50 values of 85 and 113 mu M, respectively.
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