Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 2, Pages 429-432Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np401047w
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Funding
- National Natural Science Foundations of China [41106136, 41106137]
- 12th Five-Year Science and Technology Plan for Agriculture [2012BAD32B09]
- Chinese Academy of Sciences for Key Topics in Innovation Engineering [KZCX2-YW-QN209]
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Through addition of suberoylanilide hydroxamic acid, two new aromatic norditerpenes, aspewentins A (1) and B (2), along with an oxygenated derivative, aspewentin C (3), were obtained from the culture of an Aspergillus wentii strain (na-3) isolated from the tissue of the brown alga Sargassum fusiforme. The structures and absolute configurations were unambiguously elucidated by spectroscopic analyses and quantum chemical calculations. Aspewentins A-C were produced before sporulation and exhibited potent bioactivities against some marine-derived organisms.
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