Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 2, Pages 346-350Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np4009392
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Funding
- National Natural Science Fund for Distinguished Young Scholars of China [81225023]
- National Natural Science Fund of China [41106127, 81072573, 81172978, 81302691, 81373321, 81202441]
- Shanghai Subject Chief Scientist [12XD1400200]
- National High Technology Research and Development Program of China (863 Projects) [2011AA09070107, 2013AA092902]
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Dysideanones A-C (1-3), three unusual sesquiterpene quinones with unprecedented carbon skeletons, were isolated from the South China Sea sponge Dysidea avara. Their structures including absolute configurations were determined by a combination of spectroscopic analyses and calculated ECD spectra. Within the sesquiterpene quinone structures, dysideanones A (1) and B (2) share an unprecedented 6/6/6/6-fused tetracyclic carbon skeleton, while dysideanone C (3) possesses an unusual 6/6/5/6-fused tetracyclic core. Dysideanone B (2) showed cytotoxicity against two. human cancer cell lines, HeLa and HepG2, with IC50 values of 7.1 and 9.4 mu M, respectively.
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