Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 2, Pages 416-420Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400952d
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Funding
- Jurgen-Manchot-Foundation
- BBSRC Research Development Fellowship
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Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.
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