Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 4, Pages 818-823Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np4009283
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Funding
- European Commission
- Regional Council of Reunion Island: BIOMOL-TCN program, ERDF (European Regional Development Fund) [2012-32698]
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Chemical examination of the CH2Cl2 MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 mu M.
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