Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 9, Pages 2144-2147Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500422d
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Funding
- NIH, an IRACDA postdoctoral fellowship [GM068524, GM085770, GM076324]
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While more commonly associated with plants than microbes, diterpenoid natural products have been reported to have profound effects in marine microbe-microbe interactions. Intriguingly, the genome of the marine bacterium Salinispora arenicola CNS-205 contains a putative diterpenoid biosynthetic operon, terp1. Here recombinant expression studies are reported, indicating that this three-gene operon leads to the production of isopimara-8,15-dien-19-ol (4). Although 4 is not observed in pure cultures of S. arenicola, it is plausible that the terp1 operon is only expressed under certain physiologically relevant conditions such as in the presence of other marine organisms.
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