4.7 Article

Weakly Anti-inflammatory Limonoids from the Seeds of Xylocarpus rumphii

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 9, Pages 2037-2043

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/np5003687

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Funding

  1. Thailand Research Fund
  2. Chulalongkorn University through the Royal Golden Jubilee Ph.D. Program [PHD/0009/2553]
  3. Chulalongkom University Fund (Ratchadaphiseksomphot Endownment Fund)
  4. Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University [RES560530208-AS]

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Seven new limonoids, namely, xylorumphiins EJ (1-2 and 4-7) and 2-hydroxyxylorumphiin F (3), along with three known derivatives (810), were isolated from the seeds of Xylocarpus rumphii. 2-Hydroxyxylorumphiin F (3) and xylorumphiin I (6) displayed moderate inhibitory activity against nitric oxide production from lipopolysaccharide-activated macrophages with IC50 values of 24.5 and 31.3 mu M, respectively.

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