Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 8, Pages 1962-1966Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500068y
Keywords
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Funding
- Thailand Research Fund [RSA5580023]
- Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University [RES560530208-AS]
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Rhytidenone A (1), a unique spirobisnaphthalene with a 1,7-dioxaspiro[4,4]nonan-2-one motif, and five new spirobisnaphthalenes, rhytidenones B-F (2-6), were isolated from the extract of a cultured fungal endophyte, Rhytidhysteron sp. AS21B. Their structures were elucidated mainly by analysis of NMR spectroscopic data. The structure and configuration of 1 were further confirmed by single-crystal X-ray diffraction analysis. Compounds 3 and 4 exhibited significant inhibitory activity against nitric oxide production from activated macrophages with IC50 values of 0.31 and 3.60 mu M, respectively.
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