Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 9, Pages 2124-2129Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500583z
Keywords
-
Funding
- National Natural Science Fund for Distinguished Young Scholars of China [81225023]
- National Natural Science Fund of China [81302691, 81172978, 41106127]
- Innovation Program of Shanghai Municipal Education Commission [14YZ037]
- National High Technology Research and Development Program of China (863 Projects) [2013AA092902]
- [12XD1400200]
Ask authors/readers for more resources
Nine new aaptamine derivatives (1-9), together with three known related compounds (10-12), have been isolated from the South China Sea sponge Aaptos aaptos. The structures of all compounds were unambiguously elucidated on the basis of spectroscopic analyses. Structurally, compound 1 possesses a piperidinyl group fused to a demethyl(oxy)aaptamine moiety, whereas compounds 3-6 share an imidazole-fused 1H-benzo[de][1,6]naphthyridin-2(4H)-one skeleton. The cytotoxic activities of the compounds were evaluated against various human cancer cell lines, and compounds 2, 8, 11, and 12 showed potent cytotoxicities against HL60, K562, MCF-7, KB, HepG2, and HT-29 cells, with IC50 values in the range of 0.03 to 8.5 mu M .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available