Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 2, Pages 364-369Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np401002s
Keywords
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Funding
- Marine Biotechnology Programme in Tromso (MABIT), Norway [BS0058]
- Research Council of Norway, MabCent-SFI [184688/S40]
- University of Tromso (UiT), Tromso, Norway
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Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that were isolated and characterized from the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast. The structures of natural pulmonarins A and B were tentatively elucidated by spectroscopic methods and later verified by comparison with synthetically prepared material. Both pulmonarins A and B displayed reversible, noncompetitive acetylcholinesterase inhibition comparable to several known natural acetylcholinesterase inhibitiors. Pulmonarin B was the strongest inhibitor, with an inhibition constant (K-i) of 20 mu M. In addition to reversible, noncompetitive acetylcholinesterase inhibition, the compounds displayed weak antibacterial activity but no cytotoxicity or other investigated bioactivities.
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