Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 2, Pages 388-391Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400665a
Keywords
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Funding
- Ministry of Science and Technology of China [2012AA092104, 2010CB833805]
- Chinese Academy of Sciences [XDA11030403]
- National Natural Science Foundation of China [31200039, 31125001, 31290233]
- Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002]
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Three new macrolactams, heronamides D-F (1-3), were isolated from the deep-sea-derived Streptomyces sp. SCSIO 03032 upon changing cultivation conditions. The planar structures of heronamides D-F (1-3) were elucidated by extensive MS and NMR spectroscopic analyses and comparisons with the closely related heronamides A-C. The relative configurations of 1-3 were deduced by detailed analysis of (3)J(HH) values and NOESY data. The absolute configurations of 1 and 2 were determined by chemical modifications and application of the modified Mosher's method. None of the compounds exhibited obvious antimicrobial or cytotoxic activities.
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