Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 6, Pages 1528-1531Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500285a
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Funding
- Marine Biotechnology Program, the Ministry of Oceans and Fisheries, Korea
- National Research Foundation of Korea, Ministry of Education, Science and Technology, Korea [NRF-2012M1A5A1054307]
- National Research Foundation of Korea [2012M1A5A1054307] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Anmindenols A (1) and B (2), inhibitors of inducible nitric oxide synthase (iNOS), were isolated from a marine-derived bacterium Streptomyces sp. Their chemical structures were elucidated by interpreting various spectroscopic data, including IR, MS, and NMR. Anmindenols A and B are sesquiterpenoids possessing an indene moiety with five- and six membered rings derived from isoprenyl units. The absolute configuration of C-4 in anmindenol B was determined by electronic circular dichroism (ECD) of a dimolybdenum complex. Anmindenols A (1) and B (2) inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells with IC50 values of 23 and 19 mu M, respectively.
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