Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 6, Pages 1488-1493Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500252q
Keywords
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Funding
- National Natural Science Foundation of China [41130858, 41322037, 81172977, 41176121]
- National High Technology Research and Development Program of China (863 Program) [2013AA093001]
- Natural Science Foundation of Shandong Province [ZR2011DQ019]
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Four new steroids with an acetoxy linked at the end of the side chain, echrebsteroids A-D (1-4) were obtained from the South China Sea gorgonian Echinogorgia rebekka. The absolute configurations of 1-3 were determined using the modified Mosher's method on the hydrolysis products. The isolation of the pair of epimers (2 and 3) represents the first reported separation of C-25 epimers of 26-acetoxy steroids. The (25R)-epimer (3) exhibited promising antiviral activity against respiratory syncytial virus with an IC50 value of 0.19 mu M and a comparatively higher therapeutic ratio (TC50/IC50 = 128).
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