Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 6, Pages 1390-1395Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500151b
Keywords
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Funding
- Russian Foundation for Basic Research [RFBR N 14-04-00910-a, 14-04-32052, 13-03-00986-a, 14-03-31318-mol-a]
- Russian Federation [MK-6019.2014.4]
- Program of the Presidium of the Far Eastern Branch of RAS
- Russian Federation Program for Support of the Leading Scientific Schools [148.2014.4]
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Ten new austalide meroterpenoids (1-10) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The absolute configurations of some of the metabolites were assigned by the modified Mosher's method and CD data. Compounds 1, 2, 8, and 9 were able to inhibit AP-1-dependent transcriptional activity in JB6 Cl41 cell lines at noncytotoxic concentrations. Austalides 1-5, 8, and 9 exhibited significant inhibitory activity against endo-1,3-beta-D-glucanase from a crystalline stalk of the marine mollusk Pseudocardium sachalinensis.
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