Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 7, Pages 1678-1684Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500298h
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Funding
- PRIN KFMP7Z Natural products and bioinspired molecules interfering with biological targets involved in control of tumor growth
- Grants-in-Aid for Scientific Research [25712024, 25660163] Funding Source: KAKEN
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The Mediterranean dorid nudibranch Peltodoris atromaculata that had been collected while feeding on Haliclona fulva was shown to sequester long-chain fulvinol-like polyacetylene metabolites (compounds 2-5) from the prey. They were isolated along with previously reported bromorenierins from the diethyl ether extracts of both the mollusk and the sponge. Their structures were elucidated by NMR spectroscopy and tandem FABMS analysis. Compound 5 exhibited in vitro growth inhibitory effects against the SKMEL-28 melanoma cell line.
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