Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 5, Pages 1179-1184Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500024r
Keywords
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Funding
- Natural Science Foundation of China [30873200, 41176125]
- International S&T Cooperation Program of China [0S2014GR0014]
- SMCH [XBR2013111]
- Shanghai Pujiang Program [PJ2008]
- Hungarian National Research Foundation [OTKA K105871]
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Four cyclohexanol analogues, dendrodochols A-D (1-4), were isolated from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka collected from the South China Sea. The structures were elucidated by means of detailed spectroscopic analysis. The absolute configurations were assigned using a solution TDDFT/ECD calculation approach and the modified Mosher's method. In an in vitro bioassay, these compounds exhibited no growth inhibition activity against the A549 and MG63 cell lines. Dendrodochols 1 and 3 exhibited modest antifungal activity against Candida strains, Cryptococcus neoformans, and Trichophyton rubrum, whereas 2 and 4 showed no activity against the tested strains.
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