Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 7, Pages 1700-1707Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np5003498
Keywords
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Funding
- National Natural Science Foundation of China [81303188, 81273403]
- Key National Natural Science Foundation of China [81130069]
- Program of Shanghai University of Traditional Chinese Medicine [2012JW05]
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Five new prenylated benzoylphloroglucinol derivatives, garciesculentones A-E (1-5), a new xanthone, garciesculenxanthone A (6), and 15 known compounds were isolated from the petroleum ether extract and the EtOAc-soluble fraction of a 80% (v/v) EtOH extract of Garcinia esculenta. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopic analysis and mass spectrometry. Experimental and calculated ECD and a convenient modified Mosher's method were used to determine the absolute configurations. The cytotoxicity of these compounds were evaluated by MTT assay against three human cancer cell lines (HepG2, MCF-7, and MDA-MB-231) and against normal hepatic cells (HL-7702). In addition, these isolates were evaluated for their inhibitory effects on interferon-gamma plus lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
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