Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 5, Pages 1245-1248Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500207p
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Funding
- NCI NIH HHS [P30 CA142543, U01 CA176284, R01 CA149833, P30CA142543] Funding Source: Medline
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Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 mu M.
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