Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 9, Pages 1987-1991Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np5000473
Keywords
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Funding
- Egyptian Government
- National Center for Natural Products Research, University of Mississippi, USA
- NIH NCRR [C06 RR-14503-01]
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Antileishmanial bioassay guided fractionation of Geosmithia langdonii has resulted in the isolation and identification of two new compounds (1 and 2) together with 10 known compounds (312). The structures of the isolated metabolites were elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as mass spectrometry. The absolute configuration at C4, C5, and C6 of 2 was determined as R using a modified Mosher esterification method and NOESY correlations. The extracts and the isolated metabolites were evaluated for their antileishmanial activities. Compounds 3, 9, 11, and 12 were found to be active against Leishmania donovani with IC50 values of 6.9, 3.3, 8.5, and 9.2 mu M, respectively, while compounds 1, 5, and 10 showed lower activities against L. donovani with IC50 values of 13.0, 47.3, and 34.0 mu M, respectively.
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