Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 8, Pages 1887-1892Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500362p
Keywords
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Funding
- MOST [2010CB833805, 2012AA092104]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA11030403]
- NSFC [31125001, 41106143, 41206138, 31290233]
- Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-002]
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Five new bisindole alkaloids, indimicins A-E (1-5), bearing a unique 1',3'-dimethyl-2'-hydroindole moiety, were isolated from the marine-derived Streptomyces sp. SCSIO 03032, along with two new compounds, lynamicins F and G (6 and 7). Their planar structures were elucidated by detailed interpretation of their MS and NMR spectroscopic data, and the absolute configurations were determined by X-ray crystallographic analysis (for 1), comparison of CD spectra (for 2-4), and quantum chemical calculations (for 5). Indimicin B (2) exhibited moderate cytotoxic activity toward the MCF-7 cell line.
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