Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 8, Pages 1976-1980Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500390b
Keywords
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Funding
- European Research Council [311477]
- European Community [602773]
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The biosynthesis gene cluster of the xenortides and a new derivative, xenortide D, which is produced in only trace amounts, was identified in Xenorhabdus nematophila. The structure of xenortide D was elucidated using a combination of labeling experiments followed by MS analysis and was confirmed by synthesis. Bioactivity tests revealed a weak activity of tryptarnine-carrying xenortides against Plasmodium falciparum and Trypanosoma brucei.
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