Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 10, Pages 2316-2320Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500398m
Keywords
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Funding
- Omar Magnate Family Natural Products Graduate Student Scholarship
- National Science Foundation EPSCoR [EPS-1004057]
- National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [P20RR016457]
- Office of Integrative Activities
- Office Of The Director [1004057] Funding Source: National Science Foundation
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Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(beta-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3-6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(beta-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation of AMP-activated protein kinase (AMPK). Also, this is the first report of compounds 4 and 6 from a natural source.
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