Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 4, Pages 969-975Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np401051z
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Funding
- NSF [CHE-0741968]
- Growth Regulation & Oncogenesis Training Grant NIH/NCI [T32A009523-24]
- NIH [CA100851, GM107550]
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A collection of the tropical marine cyanobacterium Symploca sp., collected near Kimbe Bay, Papua New Guinea, previously yielded several new metabolites including kimbeamides A-C, kimbelactone A, and tasihalide C. Investigations into a more polar cytotoxic fraction yielded three new lipopeptides, tasiamides C-E (1-3). The planar structures were deduced by 2D NMR spectroscopy and tandem mass spectrometry, and their absolute configurations were determined by a combination of Marfey's and chiral-phase GC-MS analysis. These new metabolites are similar to several previously isolated compounds, including tasiamide (4), grassystatins (5, 6), and symplocin A, all of which were isolated from similar filamentous marine cyanobacteria.
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