Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 10, Pages 2218-2223Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500469b
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Funding
- National Natural Science Foundation of China [41176120, 21372208]
- NSFC [U1406402]
- National High Technology Research and Development Program of China [2013AA092901]
- Program for New Century Excellent Talents in University [NCET-12-0499]
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Four new cyclic peptides, psychrophilins E-H (1-4), possessing a rare amide linkage between the carboxylic acid in anthranilic acid (ATA) and the nitrogen from an indole moiety, along with a new ATA-containing hexapeptide, versicotide C (5), were obtained from the culture of the marine-derived fungus Aspergillus versicolor ZLN-60. The structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, TDDFT ECD calculations, and Marfey's method. Versicotide C (5) is the first natural cyclic hexapeptide containing two anthranilic acids. Compounds 1-5 were not cytotoxic, and compound 3 showed potent lipid-lowering effects.
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