Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 1, Pages 132-137Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400802d
Keywords
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Funding
- NSFC [21172204, 41376148, 81373298]
- 973 program of China [2010CB833804, 2012AA092104]
- 863 program of China [2010CB833804, 2012AA092104]
- Special Fund for Marine Scientific Research in the Public Interest of China [2010418022-3]
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Three new thiodiketopiperazines, named phomazines A-C (1-3), along with 10 known analogues (4-13), were isolated from the fermentation broth of an endophytic fungus, Phoma sp. OUCMDZ-1847, associated with the mangrove plant Kandelia candel. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic, X-ray crystallographic, and Mosher's methods along with quantum ECD and C-13 NMR calculations. Compounds 2, 4, 5, 11, and 12 showed cytotoxicities against the HL-60, HCT-116, K562, MGC-803, and A549 cell lines with IC50 values in the range 0.05 to 8.5 mu M.
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