Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 12, Pages 2263-2268Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np4006025
Keywords
-
Funding
- National Natural Science Foundation of China [41206135, 41106138]
- National High Technology Research and Development Program of China [2012AA092104]
- Knowledge Innovation Program of the Chinese Academy of Sciences [KSGX2-EW-G-12]
Ask authors/readers for more resources
Four new sesquiterpenoid naphthoquinones, marfuraquinocins A-D (1-4), and two new geranylated phenazines, phenaziterpenes A (5) and B (6), were isolated from the fermentation broth of Streptomyces niveus SCSIO 3406, which originated from a South China Sea sediment sample obtained from a depth of 3536 m. The structures of 1-6 were elucidated on the basis of extensive MS and one-dimensional and two-dimensional NMR spectroscopic analyses. In a panel of cytotoxicity and antibacterial assays, 1 and 3 were found to inhibit a NCI-H460 cancer cell line with IC50 values of 3.7 and 4.4 mu M, respectively. Compounds 1, 3, and 4 exhibited antibacterial activities against. Staphylococcus aureus ATCC 29213 with equivalent MIC values of 8.0 mu g/mL; compounds 3 and 4 each showed antibacterial activity against methicillin-resistant Staphylococcus epidermidis (MRSE) shhs-E1 with MIC values of 8.0 mu g/mL.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available