Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 11, Pages 2153-2157Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np4006794
Keywords
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Funding
- Natural Sciences Foundation of China (NSFC) [81273414, 81001386]
- Beijing Natural Science Foundation [5122032]
- National Science and Technology Project of China [2014ZX09507009-008, 2012ZX09301002-003]
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A PCR-based genetic screening experiment targeting the dTDP-glucose-4,6-dehydratase gene revealed that a marine sediment-derived strain, Streptomyces sp. 7-145, had the potential to produce glycosidic antibiotics. Chemical investigation of culture extracts of this strain yielded two new 6-deoxyhexose-containing antibiotics, 11',12'-dehydroelaiophylin (1) and 11,11'-O-dimethyl-14'-deethyl-14'-methylelaiophylin (2), together with four known elaiophylin analogues (3-6). Their structures were determined by extensive NMR, MS, and CD analyses. Compounds 1, 3, 4, and 6 showed good antibacterial activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci pathogens.
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