4.7 Article

Anti-inflammatory Diterpenoids from Croton tonkinensis

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 2, Pages 230-236

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/np300699f

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Funding

  1. National Science Council of Republic of China

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Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.

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