Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 6, Pages 1052-1057Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400070x
Keywords
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Funding
- CAS [KSCX2-EW-Q-10, KSCX1-YW-R-24]
- Natural Science Foundation of Yunnan Province [2012FB178]
- NSFC [20802082, 30830115]
- 973 Programs [2009CB522300, 2009CB940900]
- Excellent Scientific and Technological Team of Yunnan Higher Education [2010CI08]
- Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team [2011HC008]
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Seven new unusual dibenzocyclooctadiene lignans, neglignans A-G (1-7), together with 16 known dibenzocyclooctadiene lignans, were isolated from the stems of Schisandra neglecta. Compounds 1 and 2 are the first dibenzocyclooctadiene lignans bearing a carboxyl group at C-4, and compounds 3 and 4 are the first 7,8-seco-dibenzocyclooctadiene lignans found from Nature. The new compounds (1-7) and several of the known compounds were evaluated for their anti-HIV activity and cytotoxicity. Compounds 2 and 6 showed anti-HIV-1 activities with therapeutic index values greater than 50, and compound 4 showed cytotoxicity against the NB4 and SHSY5Y cancer cell lines with IC50 values of 2.9 and 3.3 mu M, respectively.
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