Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 4, Pages 741-744Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300792t
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Funding
- U.S. NIH (ICBG-Panama) [2 U01TW006634-06]
- College of Agriculture and Life Sciences at the University of Arizona
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Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC50 values in the range 0.60-0.78 mu M.
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