Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 1, Pages 97-102Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300773x
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Funding
- German Academic Exchange Service (DAAD) initiative Welcome to Africa
- Ministry of Innovation, Science, Research and Technology of the State of North Rhine-Westphalia, Germany
- German Research Foundation (DFG)
- Fonds der Chemischen Industrie (FCI)
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Four new beilschmiedic acid derivatives, cryptobeilic acids A D (1-4), and tsangibeilin B (5) have been isolated from the bark of Beilschmiedia cryptocryoides collected from Madagascar. Their structures were elucidated using detailed spectroscopic and spectrometric methods. Cryptobeilic acid A (1) and tsangibeilin B (5) structures were confirmed by single-crystal X-ray diffraction analysis. Compounds 1-5 displayed moderate antibacterial activity against Escherichia coli 6r3, Acinetobacter calcoaceticus DSM 586, and Pseudonamas stutzeri A1501, with the minimum inhibitory concentrations ranging from 10 to 50 mu M, respectively. In addition, the compounds exhibited antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum strain NF54 and weak cytotoxicity against L6 cell lines.
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