Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 1, Pages 15-21Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400466j
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Funding
- NIH, National Cancer Institute [R37 CA044848]
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The microbial production, isolation, and structure elucidation of four new napyradiomycin congeners (1-4) is reported. The structures of these compounds, which are new additions to the marine-derived meroterpenoids, were defined by comprehensive spectroscopic analysis and by X-ray crystallography. Using fluorescence-activated cell sorting (FACS) analysis, napyradiomycins 1-4 were observed to induce apoptosis in the colon adenocarcinoma cell line HCT-116, indicating the possibility of a specific biochemical target for this 1 class of cytotoxins.
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