Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 5, Pages 852-857Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300815t
Keywords
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Funding
- NIH from the National Institute of Allergy and Infectious Diseases (NIAID) [AI-033066]
- Department of Health Clinical Trial and Research Center of Excellence [DOH100-TD-B-111-004]
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Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC90 0.00056-0.0068 mu M) and relatively low or no cytotoxicity (IC50 4.4-17.2 mu M). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.
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