Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 2, Pages 250-255Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300745q
Keywords
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Funding
- CAS [KSCX2-EW-Q10, KSCX1-YW-R-24]
- Natural Science Foundation of Yunnan Province [2012FB178]
- NSFC [20802082, 30830115]
- 973 programs [2009CB522300, 2009CB940900]
- Young Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]
- Key Scientific and Technological Projects of China [2009ZX09501-029]
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Seven new dibenzocyclooctadiene lignans, marlignans M S (1-7), four new norlignans, marphenols C F (8-11), and 21 known compounds (12-32) were isolated from the fruits of Schisandra wilsoniana. The structures of 1-11 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques and CD experiments. Compounds 1-11 were evaluated for their anti-HIV activities and showed EC50 values in the range 2.97-6.18 mu g/mL and therapeutic index values of 5.33-29.13.
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