Journal
JOURNAL OF NATURAL PRODUCTS
Volume 77, Issue 1, Pages 188-192Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np4008365
Keywords
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Funding
- Austrian Federal Ministry of Economy, Family and Youth
- National Foundation for Research, Technology and Development
- FWF special research project SFB Fusarium
- graduate school program Applied Bioscience Technology of the VUT in cooperation with the BOKU Vienna
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Pentahydroxyscirpene, a novel trichothecene-type compound, was isolated from Fusarium-inoculated rice. The structure of pentahydroxyscirpene was elucidated by 1D and 2D NMR spectroscopy and X-ray single-crystal diffraction. The conformation in solution was determined by NOESY experiments supported by quantum chemical calculations. In vitro toxicity tests showed that pentahydroxyscirpene inhibits protein synthesis as do other trichothecenes.
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