Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 7, Pages 1260-1266Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400143j
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Funding
- National Science Council, Taiwan [NSC 98-2323-B-037-00]
- Grants-in-Aid for Scientific Research [25108702, 25293022] Funding Source: KAKEN
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The addition of the histone deacetylase inhibitor suberoylanilide hydroxamic acid to a culture of the filamentous fungus Beauveria felina significantly changed its secondary metabolite profile and led to the isolation of eight compounds, including three new cyclodepsipeptides, desmethylisaridin E (1), desmethylisaridin C2 (2), and isaridin F (3), along with five known cyclodepsipeptide compounds. Isaridin F (3) possesses a cyclodepsipeptide ring with N-methylbutyric acid, which is rare in natural peptides. Absolute configurations of the new cyclodepsipeptides were achieved by Marfey's method. The anti-inflammatory activity of the isolated compounds was investigated through evaluating their effect on superoxide anion production and elastase release by FMLP-induced human neutrophils. Among the tested compounds, desmethylisaridin E (1) inhibited superoxide anion production and desmethylisaridin C2 (2) inhibited elastase release, with IC50 values of 10.00 +/- 0.80 and 10.01 +/- 0.46 mu M, respectively.
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