Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 1, Pages 51-58Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300655y
Keywords
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Funding
- 12th Five-Year National Science & Technology Support Program [2012BAI29B06]
- Major Projects of Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-YW-R-166]
- Global Research Network for Medicinal Plants (GRNMP)
- King Saud University
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Seven new neolignanamides (1-7), including two pairs of cis- and trans-isomers, and a new lignanamide (8) were isolated from the EtOAc-soluble fraction of an EtOH extract of the root bark of Lycium chinense, together with 22 known phenolic compounds (9-30), four of which were obtained from the genus Lycium for the first time. Compounds 5, 6, and 7 are unusual dimers having a rare connection mode between the two cinnamic acid amide units, while compounds 6, 7, and 8 are the first naturally occurring dimers derived from two dissimilar cinnamic acid amides. The cinnamic acid amides, neolignanamides, and lignanamides possess moderate radical-scavenging activity against the DPPH (2,2-diphenyl-1-picrylhydrazyl) and superoxide radicals.
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