Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 4, Pages 735-740Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300016r
Keywords
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Funding
- University of Wisconsin Madison School of Pharmacy
- Graduate School at the University of Wisconsin
- UW College of Agriculture and Life Sciences
- NIH, NIGMS [R01 GM092009]
- NSF [DMB-8415048, OIA-9977486, BIR-9214394]
- USDA
- NIH [P41RR02301, P41GM66326, RR02781, RR08438]
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A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey's method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.
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