4.7 Article

Phthalide and Isocoumarin Derivatives Produced by an Acremonium sp Isolated from a Mangrove Rhizophora apiculata

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 5, Pages 853-858

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/np200885e

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Funding

  1. Office of Higher Education Commission
  2. Thailand Research Fund [DBG5280020]
  3. Center for Innovation in Chemistry (PERCH-CIC)

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Nine new fungal metabolites, one phthalide derivative, acremonide (1), and eight isocoumarin derivatives, acremonones A-H (2-9), were isolated from the mangrove-derived fungus Acremonium sp. PSU-MA70 together with 10 known compounds. Their structures were determined by NMR analysis. The known 8-deoxytrichothecin and tricho-dermol exhibited moderate antifungal activity against Candida albicans and Cryptococcus neoformanns, respectively.

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