Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 2, Pages 202-208Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np2008335
Keywords
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Funding
- Chinese Academy of Sciences [KZCX2-YW-JC202, KZCX2-EW-G-12, KSCX2-YW-G-065, LYQY200805, 08SL111001]
- Science and Technology Planning Projects of Guangdong Province [2010B030600010, 2011B031200004]
- National Basic Research Program of China [2010CB833805]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of the State Education Ministry
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Five new C-glycoside angucyclines, named grincamycins B-F (1-5), and a known angucycline antibiotic, grincamycin (6), were isolated from Streptomyces lusitanus SCSIO LR32, an actinomycete of deep sea origin. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including MS and ID and 2D NMR experiments. All compounds except grincamycin F (5) exhibited in vitro cytotoxicities against the human cancer cell lines HepG2, SW-1990, HeLa, NCI-H460, and MCF-7 and the mouse melanoma cell line B16, with IC50 values ranging from 1.1 to 31 mu M.
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