Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 12, Pages 2251-2255Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300554f
Keywords
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Funding
- National High Technology Research and Development Program of China (863 Program) [2012AA092104]
- National Natural Science Foundation of China for Young Scientists [41106138]
- Chinese Academy of Sciences for Key Topics in Innovation Engineering [KZCX2-YW-JC202, KZCX2-EW-G-12]
- Science and Technology Planning Projects of Guangdong Province [2010B030600010, 2011B031200004]
- National Basic Research Program of China [2010CB833805]
- Chinese Academy of Sciences [08SL111001]
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A new sequential tristhiazole-thiazoline-containing cyclic peptide, marthiapeptide A (1), was isolated from a 60 L scale culture of the deep South China Sea-derived strain Marinactinospora thermotolerans SCSIO 00652. The planar structure and absolute configuration of 1 were elucidated by application of spectroscopic techniques, as well as by single-crystal X-ray diffraction and chiral-phase HPLC analysis of the acid hydrolysates. Marthiapeptide A (1) exhibited antibacterial activity against a panel of Gram-positive bacteria, with MIC values ranging from 2.0 to 8.0 mu g/mL, and displayed strong cytotoxic activity against a panel of human cancer cell lines with IC50 values ranging from 0.38 to 0.52 mu M.
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