Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 2, Pages 230-237Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np2009362
Keywords
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Funding
- National Natural Science Foundation of China [30925039]
- Beijing Natural Science Foundation [5111003]
- Ministry of Science and Technology of China [2010ZX09401-403, 2012ZX09301-003]
- Chinese Academy of Sciences [KSCX2-EW-G-6]
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The first example of a naturally occurring thiopyranchromenone, preussochromone A (1), and five other new chromone derivatives, preussochromones B-F (2-6), were isolated from solid cultures of an endolichenic fungus, Preussia africana. The structures of 1-6 were established primarily by NMR experiments, and 2 and 4 were further confirmed by X-ray crystallography. The absolute configurations of 1 and 2 were determined by the application of electronic circular dichroism (ECD), whereas those of C-5 in 3, C-6 in 4, and the 6,7-diol in 5 were deduced via the CD data of the in situ formed [Rh-2(OCOCF3)(4)] complex, the modified Mosher method, and Snatzke's method, respectively. Compounds 1 and 3 showed significant cytotoxicity against A549 cells.
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