Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 12, Pages 2152-2157Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np300566y
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22590029, 23790035]
- MEXT-Senryaku
- Tokushima Bunri University
- Grants-in-Aid for Scientific Research [23790035, 22590029, 24510293, 23790036] Funding Source: KAKEN
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Four new benzofuran derivatives, ribisin A (1), ribisin B (2), ribisin C (3), and ribisin D (4), were isolated from the MeOH extract of the fruiting bodies of Phellinus ribis. Their structures including their absolute configurations were determined by NMR and CD exciton chirality methods. Compounds 1-4 were found to promote neurite outgrowth in NGF-mediated PC12 cells at concentrations ranging from 1 to 30 mu M. The structure-activity relationships of these compounds are also discussed.
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