Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 10, Pages 1759-1764Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np3004326
Keywords
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Funding
- NIH [R01 CA149833, P01 CA095471]
- Welch Foundation [I-1689]
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Four new anthraquinone analogues including galvaquinones A-C (1-3) and an isolation artifact, 5,8-dihydroxy-2,2,4-trimethyl-6-(3-methylbutyl)-anthra[9,1-de][1,3]oxazin-7(2H)-one (4), were isolated from a marine-derived Streptomyces spinoverrucosus based on activity in an image-based assay to identify epigenetic modifying compounds. The structures of 1-4 were elucidated by comprehensive NMR and MS spectroscopic analysis. Galvaquinone B (2) was found to show epigenetic modulatory activity at 1.0 mu M and exhibited moderate cytotoxicity against non-small-cell lung cancer (NSCLC) cell lines Calu-3 and H2887.
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