Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 3, Pages 408-413Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np200814j
Keywords
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Funding
- FAPESP, Biota-FAPESP
- The Biodiversity Virtual Institute [03/02176-7]
- FAPESP
- CAPES
- CNPq
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As part of an ongoing research project on Senna and Cassia species, five new pyridine alkaloids, namely, 12'-hydroxy-7'-multijuguinol (1), 12'-hydroxy-8'-multijuguinol (2), methyl multijuguinate (3), 7'-multijuguinol (4), and 8'-multijuguinol (5), were isolated from the leaves of Senna multijuga (syn. Cassia multijuga). Their structures were elucidated on the basis of spectroscopic data analysis. Mass spectrometry was used for confirmation of the positions of the hydroxy groups in the side-chains of 1, 2, 4, and 5. All compounds exhibited weak in vitro acetylcholinesterase inhibitory activity as compared with the standard compound physostigmine.
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