Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 4, Pages 741-746Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np3000365
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Funding
- Thailand Research Fund through the Royal Golden Jubilee Ph.D. Program [PHD/0006/2552]
- TRF [RSA5280011]
- Mae Fah Luang University
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Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 mu g/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC50 values of 10.2 and 4.5 mu M, respectively.
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