Journal
JOURNAL OF NATURAL PRODUCTS
Volume 75, Issue 7, Pages 1346-1352Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np3002699
Keywords
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Funding
- National High Technology Research and Development Program of China (863 Program) [2012AA092104]
- Chinese Academy of Sciences [KZCX2-YW-JC202, KZCX2-EW-G-12, 08SL111001]
- National Natural Science Foundation of China for Young Scholars [40906076]
- Science and Technology Planning Project of Guangdong Province [2010B030600010]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of the State Education Ministry
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Metabolomic investigations focusing on the marine-derived fungus Aspergillus sp. SCSIO F063 have unveiled seven new chlorinated anthraquinones (1-7) related to averantin, together with five known analogues (11-15) when the fungus was fermented using sea salt-containing potato dextrose broth. Through the addition of sodium bromide to the broth, two new brominated anthraquinones (8, 9) and one new nonhalogenated anthraquinone (10) were obtained from the fungal mycelia. Their structures were elucidated by extensive spectroscopic analyses including MS and ID and 2D NMR data One metabolite, 6-O-methyl-7-chloroaveratin (2), displayed inhibition activity against three human tumor cell lines, SF 268, MCF-7, and NCI-H460, with IC50 values of 7.11, 6.64, and 7.42 mu M, respectively.
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